Myers, who led the Sun Devils to national titles in 2008 and 2011, is replacing Tina Deese, who was fired following the 2013 season.
"I am very excited to begin what I expect to be a challenging, rewarding and fulfilling life change with my move to become the head softball coach at Auburn University," Myers said after being announced on Friday as AU's new head coach, just the second person to have that title.
"This opportunity to coach with my family and to become part of what I feel is a total community family in the town of Auburn was one I absolutely could not pass up. Thank you for giving me and my family this 'Alabama Adventure.' We hope that you will enjoy the ride with us for years to come."
His team set an NCAA record for wins in 2008 as it posted a 66-5 record as he and his staff received the NFCA Coaching Staff of the Year award.
A 1976 graduate of Arizona State, his final Arizona State team posted a 50-12 record and advanced to the College World Series. His overall record at ASU is 427-102 and his overall record as a softball coach is 908-143.
"When we began our search for a new softball coach, the goal was to find a proven winner who could help us compete for championships," Auburn's Athletic Director Jay Jacobs said. "We could not have found a coach who better fits that criteria than Clint Myers, who has consistently reached the pinnacle of success in college softball.
"Anytime you can hire a coach who has won two national championships and been to the Women's College World Series seven out of eight years, it's obviously a huge win for your program," Jacobs added.
"No less important is the fact that Coach Myers' student-athletes have also been consistent winners in the classroom," Jacobs said. "I am delighted to welcome Coach Myers and his wife, Katie, to the Auburn family. One of the things I learned about Coach Myers during this process is how important family is to him. That will make him a great fit at Auburn."
As head coach of the Sun Devils two of his teams finished a perfect 10-0 in NCAA Tournament play and his overall NCAA Tournament record is 53-15. In his eight seasons coaching Arizona State the Sun Devils advanced to the College World Series seven times.
Before returning to his alma mater, Myers spent 19 seasons coaching softball and baseball at Central Arizona College where he posted an overall record of 887-235.
In softball he led the team to six junior college national titles and was named NJCAA National Coach of the Year six times. His teams won five consecutive national titles from 1988 through 1992.
Clint Myers is shown during a game at Arizona State.
His record in softball at Central Arizona was 481-43 while his baseball teams posted an overall mark of 406-192 from 1996-2005 and he was named juco national baseball coach of the year in 2002.
A standout baseball player at Lakewood, Calif., High, he played baseball at Arizona State and played minor league ball in the St. Louis Cardinals organization. He advanced to the AAA level before retiring as a participant to begin his coaching career.
The coach he is replacing, Deese, has taken a position at Beauregard High School in south Lee County.